Research Paper: The novel mitochondria activator, 10-ethyl-3-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (TND1128), promotes the development of hippocampal neuronal morphology

Author: Professor Asafumi Nagamatsu (Sojo University)

Summary

Sirtuin genes are expected to be effective in improving mitochondrial function, which can prevent dementia, arteriosclerosis, and hearing loss, promote fat burning and cell repair, and remove reactive oxygen species. Additionally, Professor Imai has proposed that the Sirt2 protein, which halts the transcription of telomeres and lysosomal DNA, is activated by promoting the biosynthesis of NAD+, potentially offering anti-aging effects. The Sirt2 protein is an NAD+-dependent histone deacetylase enzyme. Furthermore, it has been reported that NMN, an intermediate in the synthesis of NAD+, contributes to the production of NAD+.

Long-term feeding of mice with a diet containing NMN has been shown to promote the production of NAD+ in tissues and suppress the decline in physiological functions associated with aging. These results indicate that NAD+ is an essential substance for energy production in the initial stages of oxidative phosphorylation in mitochondria and in the oxidative reactions of the TCA cycle. In our research, β-NMN did not show strong effects, but a slight increase in dendritic branching may be related to NAD+ production. However, the effects of 5-deazaflavin (TND1128) were more significant than those of β-NMN, suggesting that 5-deazaflavin (TND1128) might be a more effective component for enhancing vitality and preventing aging (including the prevention and improvement of various neurodegenerative diseases) than β-NMN.

actual paper

https://pubmed.ncbi.nlm.nih.gov/33989906/